Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 10/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867475 | 0.88 | POLB (0.55) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867479 | 0.85 | POLB (0.49) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867573 | 0.85 | PYGM (0.51) | ACHESMN1; SMN2ALDH1A1 | |
| SCHEMBL23867515 | 0.84 | POLB (0.47) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867474 | 0.83 | SRC (0.51) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867525 | 0.80 | HTR2A (0.49) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867512 | 0.75 | ACHE (0.50) | POLBACHESRCDRD2HTR2A | |
| SCHEMBL23859942 | 0.73 | POLB (0.55) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867516 | 0.72 | POLB (0.53) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL30979648 | 0.72 | POLB (0.66) | POLBSMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |