Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10330598 | 0.84 | RAB9A (0.71) | MAPTRAB9ACYP1A2POLBNPC1 | |
| SCHEMBL14320027 | 0.83 | CYP1A2 (0.69) | MAPTRAB9ACYP1A2POLBNPC1 | |
| SCHEMBL23221555 | 0.80 | ABCG2 (0.66) | MAPTRAB9ACYP1A2POLBNPC1 | |
| SCHEMBL4915813 | 0.78 | NOS3 (0.60) | MAPTRAB9APOLBNPC1GAA | |
| SCHEMBL11608377 | 0.77 | CA1 (0.58) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL20354983 | 0.75 | POLB (0.61) | MAPTCYP1A2POLBGAACYP3A4 | |
| SCHEMBL12218261 | 0.69 | RAB9A (0.76) | MAPTRAB9ACYP1A2POLBNPC1 | |
| SCHEMBL4012756 | 0.69 | RAB9A (0.71) | MAPTRAB9ACYP1A2NPC1GAA | |
| SCHEMBL4212835 | 0.69 | NPC1 (0.58) | MAPTRAB9ACYP1A2POLBNPC1 | |
| SCHEMBL12218264 | 0.69 | RAB9A (0.76) | MAPTRAB9ACYP1A2POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |