Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.56 |
| ▸ | KDM1A | O60341 | 2/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743109 | 0.89 | FOLH1 (0.57) | MRGPRX4FOLH1HTTPARP1PARP10 | |
| SCHEMBL2897224 | 0.88 | MRGPRX4 (0.62) | NPC1MRGPRX4KDM1AFOLH1PTGER1 | |
| SCHEMBL28964566 | 0.85 | NPC1 (0.56) | NPC1MRGPRX4KDM1AFOLH1PTGER1 | |
| SCHEMBL2892814 | 0.84 | NPC1 (0.55) | NPC1MRGPRX4KDM1AFOLH1HTT | |
| SCHEMBL19285699 | 0.84 | KDM1A (0.50) | NPC1MRGPRX4KDM1AFOLH1HTT | |
| SCHEMBL6358665 | 0.83 | MAOB (0.56) | MRGPRX4FOLH1HTTPARP1PARP10 | |
| SCHEMBL11464594 | 0.83 | FOLH1 (0.52) | MRGPRX4FOLH1HTTPARP1PARP10 | |
| SCHEMBL4599397 | 0.82 | RXRA (0.60) | NPC1MRGPRX4FOLH1HTTMAPT | |
| SCHEMBL28964567 | 0.81 | NPC1 (0.51) | NPC1MRGPRX4KDM1AFOLH1PTGER1 | |
| SCHEMBL3032568 | 0.80 | PLAU (0.51) | NPC1MRGPRX4HTTPARP10PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624567-B1 | Derivatives of 3-fluorophenol, process for their preparation and their use | CLARIANT GMBH (DE) | 1999-12-08 | — | — | EP | claimed |
| EP-0624567-A2 | Derivatives of 3-fluorophenol, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-17 | — | — | EP | claimed |
| CN-115028680-B | PROTAC compound for targeted degradation of Cyclophilin A and preparation method and application thereof | 深圳湾实验室 | 2023-01-20 | — | — | CN | disclosed |
| CN-115028680-A | PROTAC compound for targeted degradation of Cyclophilin A and preparation method and application thereof | 深圳湾实验室 | 2022-09-09 | — | — | CN | disclosed |
| US-20110294749-A1 | DIAMINOPYRIMIDINECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-12-01 | — | — | US | disclosed |
| EP-1518855-B1 | DIAMINOPYRIMIDINECARBOXA MIDE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2011-10-26 | — | — | EP | disclosed |
| US-8012959-B2 | Diaminopyrimidinecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2011-09-06 | — | — | US | disclosed |
| CN-101880246-A | Substituted benzoyl urea compound and preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2010-11-10 | — | — | CN | disclosed |
| US-7645781-B2 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives | PFIZER INC (US) | 2010-01-12 | — | — | US | disclosed |
| US-20090281072-A1 | Diaminopyrimidinecarboxamide Derivative | ASTELLAS PHARM INC. (JP) | 2009-11-12 | — | — | US | disclosed |
| US-7449456-B2 | Diaminopyrimidinecarboxamide derivative | ASTELLAS PHARMA, INC. (JP) | 2008-11-11 | — | — | US | disclosed |
| EP-1478629-A1 | N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-24 | — | — | EP | disclosed |
| US-20040147760-A1 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives | PHARMACIA & UPJOHN COMPANY | 2004-07-29 | — | — | US | disclosed |
| US-20040044052-A1 | N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives | PHARMACIA & UPJOHN COMPANY | 2004-03-04 | — | — | US | disclosed |
| WO-2003072553-A1 | N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATES AND THEIR USE AS ANTIBACTERIALS | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |
| EP-0624567-B1 | Derivatives of 3-fluorophenol, process for their preparation and their use | CLARIANT GMBH (DE) | 1999-12-08 | — | — | EP | disclosed |
| EP-0628536-B1 | Process for the preparation of aromatic amines | CLARIANT GMBH (DE) | 1999-07-14 | — | — | EP | disclosed |
| US-5410082-A | Process for preparing amines | CLARIANT GMBH (DE) | 1995-04-25 | — | — | US | disclosed |
| EP-0628536-A2 | Process for the preparation of amines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-14 | — | — | EP | disclosed |
| EP-0624567-A2 | Derivatives of 3-fluorophenol, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147760-A1 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives | OXA1L, AADAC, MT-ND5 | NPC1 2741/4885MRGPRX4 4083/4885KDM1A 1528/4885 |
| US-20040044052-A1 | N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives | OXA1L, AADAC, MT-ND5 | NPC1 2741/4885MRGPRX4 4083/4885KDM1A 1528/4885 |
| US-20110294749-A1 | DIAMINOPYRIMIDINECARBOXAMIDE DERIVATIVE | STAT6, STAT4, STAT3 | NPC1 4203/4885MRGPRX4 1053/4885KDM1A 819/4885 |
| US-20090281072-A1 | Diaminopyrimidinecarboxamide Derivative | STAT6, STAT4, STAT3 | NPC1 4203/4885MRGPRX4 1053/4885KDM1A 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.