MT-ND5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8492838	0.52	4/20
SCHEMBL8492845	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
SCHEMBL8494171	0.50	4/20
SCHEMBL8494175	0.50	4/20
SCHEMBL8494177	0.50	4/20
7-Prenyloxycoumarin (SCHEMBL4898255)	0.79	3/20
SCHEMBL712741	0.57	3/20
Geiparvarin (SCHEMBL2532495)	0.56	3/20

Clinical trials — most relevant to MT-ND5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease	PHASE2	RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Diagnostic Odyssey Survey 2	nan	COMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
mtDNA Mutation Load Analysis in Mesoangioblasts	nan	RECRUITING
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis	nan	UNKNOWN
EPI-743 for Mitochondrial Respiratory Chain Diseases	nan	NO_LONGER_AVAILABLE
Survey on Supplement Use in Mitochondrial Disease	nan	COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
A RETROspective Study of Patients With TK2d	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MT-ND5 binder may also engage these)

Protein	Name	Similarity
P03916	—	1.000	P03916 →
P03918	—	1.000	P03918 →
P03917	—	1.000	P03917 →
Q35648	—	1.000	Q35648 →
P03919	—	1.000	P03919 →
P92699	—	1.000	P92699 →
P41299	—	1.000	P41299 →
P24978	—	1.000	P24978 →
P48176	—	1.000	P48176 →
O03205	—	1.000	O03205 →
P48656	—	1.000	P48656 →
Q76LN2	—	1.000	Q76LN2 →
Q9TA19	—	1.000	Q9TA19 →
P92669	—	1.000	P92669 →
Q36459	—	1.000	Q36459 →
Q9ZZ44	—	0.999	Q9ZZ44 →
P18940	—	0.999	P18940 →
Q4JQH7	—	0.998	Q4JQH7 →
Q95885	—	0.998	Q95885 →
Q953I4	—	0.998	Q953I4 →
P11661	—	0.997	P11661 →
Q9ZZY1	—	0.997	Q9ZZY1 →
P38602	—	0.996	P38602 →
Q9ZZM3	—	0.996	Q9ZZM3 →
Q38PR2	—	0.996	Q38PR2 →
Q1HK80	—	0.996	Q1HK80 →
Q35813	—	0.996	Q35813 →
Q2I3G4	—	0.995	Q2I3G4 →
P92485	—	0.995	P92485 →
O63908	—	0.995	O63908 →