Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 4/20 | 0.48 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26972626 | 1.00 | GRM1 (0.48) | GRM1PLD1HRH3SMN1; SMN2ALDH1A1 | |
| SCHEMBL18553331 | 1.00 | GRM1 (0.48) | GRM1PLD1HRH3SMN1; SMN2ALDH1A1 | |
| SCHEMBL15201158 | 0.89 | HRH3 (0.50) | GRM1HRH3SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14360624 | 0.89 | HRH3 (0.50) | GRM1HRH3SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27268114 | 0.88 | LMNA (0.50) | GRM1HRH3SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL16269503 | 0.84 | GRM1 (0.45) | GRM1PLD1HRH3ALDH1A1MAPT | |
| SCHEMBL29442179 | 0.78 | ATR (0.55) | ALDH1A1KDM4E | |
| SCHEMBL20129603 | 0.78 | PLD1 (0.54) | GRM1PLD1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20141500 | 0.78 | PLD1 (0.54) | GRM1PLD1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2127456 | 0.78 | ATR (0.55) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021194878-A1 | SELECTIVE MODULATORS OF MUTANT LRRK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-09-30 | — | — | WO | disclosed |