Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.68 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.62 |
| ▸ | OSBP | P22059 | 1/20 | 0.62 |
| ▸ | RORC | P51449 | 1/20 | 0.62 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.62 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GBA1 | P04062 | 1/20 | 0.54 |
| ▸ | UGCG | Q16739 | 1/20 | 0.54 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12325985 | 0.98 | CYP46A1 (0.68) | POLA1CYP46A1USP2LMNAABCB1 | |
| SCHEMBL14564247 | 0.95 | POLA1 (0.65) | POLA1CYP46A1USP2LMNAABCB1 | |
| SCHEMBL20620339 | 0.94 | POLA1 (0.62) | POLA1CYP46A1USP2LMNAABCB1 | |
| SCHEMBL16158084 | 0.94 | POLA1 (0.62) | POLA1CYP46A1USP2LMNAABCB1 | |
| SCHEMBL16172138 | 0.93 | PLA2G2A (0.62) | POLA1CYP46A1USP2LMNAABCB1 | |
| SCHEMBL19115392 | 0.93 | POLA1 (0.61) | POLA1CYP46A1USP2LMNAABCB1 | |
| SCHEMBL24435883 | 0.93 | PLA2G2A (0.62) | POLA1CYP46A1USP2LMNAABCB1 | |
| SCHEMBL16174261 | 0.93 | PLA2G2A (0.62) | POLA1CYP46A1USP2LMNAABCB1 | |
| SCHEMBL330612 | 0.93 | POLA1 (0.77) | POLA1CYP46A1USP2LMNAABCB1 | |
| SCHEMBL26910780 | 0.93 | POLA1 (0.77) | POLA1CYP46A1USP2LMNAABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11207416-B2 | Compositions and methods for targeted RNA delivery | VERVE THERAPEUTICS, INC. (US) | 2021-12-28 | — | — | US | disclosed |
| US-20210299261-A1 | COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY | VERVE THERAPEUTICS, INC. | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11207416-B2 | Compositions and methods for targeted RNA delivery | PCSK9, LDLR, PCSK7 | POLA1 1872/4885CYP46A1 68/4885USP2 1057/4885 |
| US-20210299261-A1 | COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY | PCSK9, LDLR, PCSK7 | POLA1 1872/4885CYP46A1 68/4885USP2 1057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.