Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.36 |
| ▸ | KDR | P35968 | 8/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26534233 | 0.80 | NOS1 (0.43) | EGFRKDRMEN1NPC1HTT | |
| SCHEMBL26485086 | 0.78 | EGFR (0.35) | EGFRKDRPDGFRBPDGFRAMEN1 | |
| SCHEMBL23877251 | 0.73 | KDM4E (0.36) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL18054845 | 0.71 | ALDH1A1 (0.40) | TBK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL10507830 | 0.68 | KDM4E (0.49) | MEN1NPC1HTTRAB9AKMT2A | |
| SCHEMBL20752018 | 0.68 | MCL1 (0.38) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL20751936 | 0.67 | SMN1; SMN2 (0.40) | TBK1MEN1NPC1HTTRAB9A | |
| SCHEMBL20321522 | 0.67 | ALDH1A1 (0.37) | EGFRKDRMEN1NPC1HTT | |
| SCHEMBL12929968 | 0.67 | TNKS (0.48) | TBK1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20751959 | 0.67 | CYP2A6 (0.36) | MEN1HTTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021194914-A1 | SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-09-30 | — | — | WO | disclosed |