SCHEMBL23877445

SCHEMBL23877445

CC(C)(C)S(=O)(=O)Nc1ccc(C#N)cc1C(=O)NC12CC(C(F)(F)F)(C1)C2

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PDK1 Q15118 1/20 0.36
▸ PDK2 Q15119 1/20 0.36
▸ PDK3 Q15120 1/20 0.36
▸ PDK4 Q16654 1/20 0.36
▸ DDR1 Q08345 2/20 0.35
▸ SLC22A12 Q96S37 2/20 0.35
▸ TMPRSS4 Q9NRS4 1/20 0.34
▸ TBXA2R P21731 5/20 0.34
▸ ELANE P08246 1/20 0.34
▸ ALB P02768 1/20 0.32
▸ TRPV4 Q9HBA0 1/20 0.32
▸ NR1H2 P55055 1/20 0.32
▸ NR1H3 Q13133 1/20 0.32
▸ CXCR5 P32302 1/20 0.32
▸ TNF P01375 2/20 0.31
▸ IRAK4 Q9NWZ3 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30547579 1.00 PDK1 (0.36) PDK1PDK2PDK3PDK4DDR1
SCHEMBL23877457 0.93 DDR1 (0.38) PDK1PDK2PDK3PDK4DDR1
SCHEMBL23877569 0.85 CNR2 (0.39) SLC22A12
SCHEMBL31046860 0.85 CNR2 (0.39) SLC22A12
SCHEMBL23877560 0.85 MRGPRX1 (0.39) PDK1PDK2PDK3PDK4
SCHEMBL22820229 0.85 KDM1A (0.40) DDR1CXCR5
SCHEMBL23877476 0.84 TBXA2R (0.35) SLC22A12TBXA2RALBCXCR5
SCHEMBL26188695 0.83 PDK1 (0.36) PDK1PDK2PDK3PDK4DDR1
SCHEMBL23877625 0.83 PARP14 (0.38) PDK1PDK2PDK3PDK4DDR1
SCHEMBL23877495 0.82 TNF (0.35) PDK1PDK2PDK3PDK4DDR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2026-04-21 — — US disclosed
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO, INC. 2024-12-12 — — US disclosed
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2024-07-30 — — US disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES GILEAD SCIENCES, INC. 2022-02-24 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B PDK1 2441/4885PDK2 1094/4885PDK3 1799/4885
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B PDK1 2441/4885PDK2 1094/4885PDK3 1799/4885
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives NR3C2, NR5A1, SRD5A2 PDK1 1922/4885PDK2 1680/4885PDK3 1869/4885
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B PDK1 2441/4885PDK2 1094/4885PDK3 1799/4885
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B PDK1 2441/4885PDK2 1094/4885PDK3 1799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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