SCHEMBL23877456

SCHEMBL23877456

CC(C)(C)c1ccc(C(=O)NC23CC(c4ccccc4)(C2)C3)c(NS(=O)(=O)c2ccc(S(C)(=O)=O)cc2)c1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HSD17B2 P37059 4/20 0.42
▸ UQCRB P14927 1/20 0.42
▸ ACLY P53396 1/20 0.40
▸ MCL1 Q07820 1/20 0.40
▸ USP2 O75604 4/20 0.40
▸ USP8 P40818 4/20 0.40
▸ PSD A5PKW4 1/20 0.39
▸ CA1 P00915 1/20 0.39
▸ CA2 P00918 1/20 0.39
▸ BCL2A1 Q16548 1/20 0.39
▸ KIF18A Q8NI77 1/20 0.38
▸ PTPN5 P54829 1/20 0.38
▸ KDM1A O60341 1/20 0.38
▸ PGAM1 P18669 1/20 0.38
▸ CCR9 P51686 2/20 0.38
▸ USP36 Q9P275 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23877572 0.92 USP2 (0.49) ACLYUSP2USP8KDM1AUSP36
SCHEMBL23877434 0.87 AVPR2 (0.42) USP2USP8
SCHEMBL30547601 0.86 KCNA5 (0.46) —
SCHEMBL23877537 0.85 KDM1A (0.41) HSD17B2UQCRBACLYUSP2USP8
SCHEMBL23877605 0.85 USP2 (0.49) USP2USP8
SCHEMBL23877443 0.84 KDM1A (0.51) ACLYUSP2USP8KDM1ACCR9
SCHEMBL23877426 0.84 HSD17B2 (0.38) HSD17B2UQCRBPSDKIF18APTPN5
SCHEMBL23877636 0.83 GPR27 (0.42) ACLYCCR9
SCHEMBL23877582 0.82 USP2 (0.47) ACLYUSP2USP8KDM1AUSP36
SCHEMBL23877597 0.81 KCNA5 (0.53) ACLYCCR9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2026-04-21 — — US disclosed
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO, INC. 2024-12-12 — — US disclosed
CN-118791407-A Sulfinylamino group benzamide and process for preparing same Sulfonylamino benzamide derivatives 奥索生物公司 2024-10-18 — — CN disclosed
CN-118638096-A Sulfinylamino group benzamide and process for preparing same Sulfonylamino benzamide derivatives 奥索生物公司 2024-09-13 — — CN disclosed
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2024-07-30 — — US disclosed
CN-112204008-B Sulfonylaminobenzamides and sulfonylaminobenzamide derivatives 奥索生物公司 2024-07-05 — — CN disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES GILEAD SCIENCES, INC. 2022-02-24 — — US disclosed
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES GILEAD SCIENCES, INC. 2022-02-24 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B HSD17B2 720/4885UQCRB 719/4885ACLY 2228/4885
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B HSD17B2 720/4885UQCRB 719/4885ACLY 2228/4885
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives NR3C2, NR5A1, SRD5A2 HSD17B2 38/4885UQCRB 728/4885ACLY 1624/4885
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B HSD17B2 720/4885UQCRB 719/4885ACLY 2228/4885
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B HSD17B2 720/4885UQCRB 719/4885ACLY 2228/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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