SCHEMBL23877458

SCHEMBL23877458

O=C(NC12CC(C(F)(F)F)(C1)C2)c1cc(C(F)(F)F)ccc1NS(=O)(=O)C1COC1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.38
MRGPRX1 Q96LB2 5/20 0.36
LIPC P11150 1/20 0.34
LIPG Q9Y5X9 1/20 0.34
PDE2A O00408 2/20 0.33
ACLY P53396 1/20 0.33
TSPO P30536 1/20 0.32
CCR9 P51686 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30547577 1.00 KDM1A (0.38) KDM1AMRGPRX1LIPCLIPGPDE2A
SCHEMBL31046841 0.90 MRGPRX1 (0.38) KDM1AMRGPRX1LIPCLIPGACLY
SCHEMBL23877585 0.90 MRGPRX1 (0.38) KDM1AMRGPRX1LIPCLIPGACLY
SCHEMBL23877624 0.85 MRGPRX1 (0.38) KDM1AMRGPRX1LIPCLIPGACLY
SCHEMBL23877610 0.85 KDM1A (0.41) KDM1ALIPCLIPGACLY
SCHEMBL23877547 0.83 KDM1A (0.35) KDM1AMRGPRX1LIPCLIPGTSPO
SCHEMBL30547561 0.83 KDM1A (0.35) KDM1AMRGPRX1LIPCLIPGTSPO
SCHEMBL22820229 0.81 KDM1A (0.40) KDM1ALIPCLIPGACLY
SCHEMBL26188612 0.81 LIPC (0.35) LIPCLIPGPDE2A
SCHEMBL23877527 0.81 KDM1A (0.39) KDM1ALIPCLIPGACLY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2026-04-21 US disclosed
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO, INC. 2024-12-12 US disclosed
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2024-07-30 US disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 EP disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 EP disclosed
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES GILEAD SCIENCES, INC. 2022-02-24 US disclosed
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES GILEAD SCIENCES, INC. 2022-02-24 US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B KDM1A 2735/4885MRGPRX1 1500/4885LIPC 2934/4885
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B KDM1A 2735/4885MRGPRX1 1500/4885LIPC 2934/4885
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives NR3C2, NR5A1, SRD5A2 KDM1A 4072/4885MRGPRX1 2156/4885LIPC 1288/4885
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B KDM1A 2735/4885MRGPRX1 1500/4885LIPC 2934/4885
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B KDM1A 2735/4885MRGPRX1 1500/4885LIPC 2934/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.