Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 13/20 | 0.34 |
| ▸ | FLT3 | P36888 | 8/20 | 0.33 |
| ▸ | KIT | P10721 | 6/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 5/20 | 0.32 |
| ▸ | PRKACA | P17612 | 5/20 | 0.32 |
| ▸ | FLT1 | P17948 | 5/20 | 0.32 |
| ▸ | LCK | P06239 | 4/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.32 |
| ▸ | PLK4 | O00444 | 4/20 | 0.32 |
| ▸ | AURKA | O14965 | 4/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.32 |
| ▸ | MARK3 | P27448 | 4/20 | 0.32 |
| ▸ | MARK2 | Q7KZI7 | 4/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20132921 | 0.84 | ROCK2 (0.33) | ROCK1CLK4CDK8KDRFLT3 | |
| SCHEMBL20132981 | 0.74 | PDPK1 (0.33) | ROCK1CDK5CLK4CDK8KDR | |
| SCHEMBL16475286 | 0.71 | PDPK1 (0.56) | ROCK1CDK5CLK4CDK8KDR | |
| SCHEMBL19786404 | 0.69 | — | — | |
| SCHEMBL26420402 | 0.65 | — | — | |
| SCHEMBL19104285 | 0.65 | PDPK1 (0.42) | ROCK1CDK5CLK4KDRFLT3 | |
| SCHEMBL22349086 | 0.64 | KDR (0.37) | ROCK1CDK5CLK4KDRFLT3 | |
| SCHEMBL18368384 | 0.62 | CYP1A2 (0.41) | ROCK1CDK5CLK4CDK8KDR | |
| SCHEMBL569660 | 0.62 | GAA (0.61) | ROCK1CDK5CLK4CDK8KDR | |
| SCHEMBL13236555 | 0.61 | PDPK1 (0.56) | ROCK1CDK5CLK4CDK8KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136308-B2 | Substituted quinazoline and quinazolinone compounds and methods of use thereof | ARAXES PHARMA LLC (US) | 2021-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136308-B2 | Substituted quinazoline and quinazolinone compounds and methods of use thereof | KRAS, NRAS, HRAS | ROCK1 111/4885CDK5 788/4885CLK4 768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.