Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 13/20 | 0.33 |
| ▸ | PER2 | O15055 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21947327 | 0.85 | ROCK2 (0.36) | MCHR1PER2ROCK2 | |
| SCHEMBL19128867 | 0.85 | ROCK2 (0.35) | MCHR1ROCK2 | |
| SCHEMBL20647067 | 0.83 | ROCK2 (0.34) | MCHR1ROCK2 | |
| SCHEMBL20654134 | 0.74 | ROCK2 (0.49) | ROCK2 | |
| SCHEMBL23888979 | 0.74 | ROCK2 (0.33) | MCHR1ROCK2 | |
| SCHEMBL19150022 | 0.72 | ERN1 (0.42) | MCHR1ROCK2 | |
| SCHEMBL23888984 | 0.71 | CNR2 (0.35) | MCHR1ROCK2 | |
| SCHEMBL17875244 | 0.65 | MCHR1 (0.57) | MCHR1KMT2A | |
| SCHEMBL19128207 | 0.63 | ALDH1A1 (0.41) | PIM1MEN1KMT2A | |
| SCHEMBL20653915 | 0.63 | ROCK2 (0.39) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954681-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | Bristol-Myers Squibb Company (US) | 2022-02-16 | — | — | EP | disclosed |
| EP-3402790-B1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2021-10-06 | — | — | EP | disclosed |