Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 5/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 8/20 | 0.35 |
| ▸ | JAK1 | P23458 | 8/20 | 0.35 |
| ▸ | TYK2 | P29597 | 8/20 | 0.35 |
| ▸ | JAK3 | P52333 | 8/20 | 0.35 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17321452 | 0.89 | PDE2A (0.39) | ROCK2RETPDE2A | |
| SCHEMBL24247760 | 0.87 | DRD2 (0.38) | ROCK2PLA2G4APDE2A | |
| SCHEMBL17321454 | 0.87 | KDM4E (0.41) | — | |
| SCHEMBL21946575 | 0.86 | PDE2A (0.37) | ROCK2RETPDE2A | |
| SCHEMBL17452665 | 0.86 | ROCK2 (0.49) | ROCK2PLA2G4APDE2A | |
| SCHEMBL21948591 | 0.86 | ROCK2 (0.40) | ROCK2PLA2G4APDE2A | |
| SCHEMBL20646896 | 0.85 | HAT1 (0.38) | ROCK2RETPLA2G4APDE2A | |
| SCHEMBL20647180 | 0.85 | HAT1 (0.38) | ROCK2RETPLA2G4APDE2A | |
| SCHEMBL21947339 | 0.85 | ROCK2 (0.44) | ROCK2PDE2A | |
| SCHEMBL21947337 | 0.85 | ROCK2 (0.39) | ROCK2RETPLA2G4APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3402790-B1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2021-10-06 | — | — | EP | disclosed |