Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21947204 | 0.88 | ROCK2 (0.39) | ROCK2TYK2 | |
| SCHEMBL19127292 | 0.86 | SPR (0.43) | ROCK2PLATTYK2 | |
| SCHEMBL21948585 | 0.85 | ROCK2 (0.39) | ROCK2PLAT | |
| SCHEMBL20647176 | 0.85 | ROCK2 (0.38) | ROCK2TYK2 | |
| SCHEMBL21948590 | 0.80 | ROCK2 (0.39) | ROCK2PLAT | |
| SCHEMBL21947307 | 0.79 | ROCK2 (0.37) | ROCK2PLAT | |
| SCHEMBL19902682 | 0.78 | ROCK2 (0.52) | ROCK2 | |
| SCHEMBL20229595 | 0.78 | PLAT (0.43) | ROCK2PLAT | |
| SCHEMBL21947213 | 0.77 | PLAT (0.39) | ROCK2PLAT | |
| SCHEMBL21946550 | 0.76 | MAPK8 (0.38) | ROCK2PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954681-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | Bristol-Myers Squibb Company (US) | 2022-02-16 | — | — | EP | disclosed |
| EP-3402790-B1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2021-10-06 | — | — | EP | disclosed |