Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23889192 | 0.86 | USP30 (0.34) | ROCK2USP30 | |
| SCHEMBL23888968 | 0.81 | ROCK2 (0.46) | ROCK2USP30 | |
| SCHEMBL23889137 | 0.73 | ROCK2 (0.38) | ROCK2 | |
| SCHEMBL20647136 | 0.72 | ROCK2 (0.43) | ROCK2 | |
| SCHEMBL24247696 | 0.72 | ROCK2 (0.44) | ROCK2 | |
| SCHEMBL21947210 | 0.71 | ROCK2 (0.55) | ROCK2 | |
| SCHEMBL20646787 | 0.71 | ROCK2 (0.43) | ROCK2 | |
| SCHEMBL20647126 | 0.70 | ROCK2 (0.40) | ROCK2USP30 | |
| SCHEMBL20647027 | 0.69 | USP30 (0.44) | ROCK2USP30 | |
| SCHEMBL20646780 | 0.68 | SIK1 (0.48) | ROCK2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3402790-B1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2021-10-06 | — | — | EP | disclosed |