Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20647103 | 0.83 | ROCK2 (0.49) | ROCK2 | |
| SCHEMBL20646972 | 0.83 | ROCK2 (0.59) | ROCK2 | |
| SCHEMBL21948609 | 0.81 | ROCK2 (0.45) | ROCK2 | |
| SCHEMBL23889137 | 0.76 | ROCK2 (0.38) | ROCK2 | |
| SCHEMBL20647072 | 0.74 | ROCK2 (0.60) | ROCK2 | |
| SCHEMBL23889198 | 0.72 | ROCK2 (0.40) | ROCK2 | |
| SCHEMBL20647109 | 0.71 | ROCK2 (0.46) | ROCK2 | |
| SCHEMBL21947251 | 0.71 | ROCK2 (0.72) | ROCK2 | |
| SCHEMBL20646744 | 0.70 | ROCK2 (0.60) | ROCK2 | |
| SCHEMBL20647057 | 0.69 | ROCK2 (0.82) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954681-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | Bristol-Myers Squibb Company (US) | 2022-02-16 | — | — | EP | disclosed |