Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.50 |
| ▸ | JAK3 | P52333 | 20/20 | 0.50 |
| ▸ | JAK1 | P23458 | 15/20 | 0.50 |
| ▸ | JAK2 | O60674 | 14/20 | 0.50 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22054114 | 0.84 | TYK2 (0.58) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL31304735 | 0.84 | TYK2 (0.58) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23878845 | 0.84 | TYK2 (0.58) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL26323063 | 0.73 | JAK3 (0.78) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL24065215 | 0.73 | PAK4 (0.49) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL29565856 | 0.73 | TYK2 (0.75) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL18269689 | 0.73 | TYK2 (0.75) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL29512168 | 0.73 | TYK2 (0.75) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23889388 | 0.72 | TYK2 (0.41) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23889370 | 0.72 | PLK4 (0.37) | TYK2JAK3JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |