Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 18/20 | 0.41 |
| ▸ | JAK3 | P52333 | 18/20 | 0.41 |
| ▸ | JAK1 | P23458 | 16/20 | 0.41 |
| ▸ | JAK2 | O60674 | 16/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22054133 | 0.85 | JAK3 (0.48) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL23879013 | 0.85 | JAK3 (0.48) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL23889532 | 0.83 | EIF2AK4 (0.41) | JAK3JAK1JAK2 | |
| SCHEMBL23889370 | 0.75 | PLK4 (0.37) | TYK2JAK3JAK1JAK2SYK | |
| SCHEMBL23889522 | 0.73 | PAK1 (0.46) | TYK2JAK3JAK1JAK2RET | |
| SCHEMBL23889440 | 0.73 | NTRK1 (0.45) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL23889360 | 0.72 | TYK2 (0.50) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23878776 | 0.72 | TYK2 (0.65) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL22055017 | 0.72 | TYK2 (0.65) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL24174490 | 0.72 | JAK3 (0.43) | TYK2JAK3JAK1JAK2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |