Ethinyl Estradiol

Ethinyl Estradiol

SCHEMBL2389175

C#C[C@@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CCC21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ESR1

The experimentally established mechanism targets of Ethinyl Estradiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 known ✓ P03372 8/20 1.00
CYP3A4 P08684 3/20 1.00
ESR2 Q92731 3/20 1.00
NR3C1 P04150 3/20 1.00
PGR P06401 3/20 1.00
ABCB11 O95342 2/20 1.00
SLC6A2 P23975 2/20 1.00
SLC6A4 P31645 2/20 1.00
SLC6A3 Q01959 2/20 1.00
SLC22A2 O15244 1/20 1.00
NR1I2 O75469 1/20 1.00
SHBG P04278 1/20 1.00
HTR1A P08908 1/20 1.00
ADORA3 P0DMS8 1/20 1.00
AR P10275 1/20 1.00
ADRB3 P13945 1/20 1.00
CYP2B6 P20813 1/20 1.00
TBXA2R P21731 1/20 1.00
UGT1A1 P22309 1/20 1.00
PDE4A P27815 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethinyl Estradiol SCHEMBL15213118 1.00 ESR1 (1.00) ESR1CYP3A4ESR2NR3C1PGR
Ethinyl Estradiol SCHEMBL13575761 1.00 ESR1 (1.00) ESR1CYP3A4ESR2NR3C1PGR
Ethinyl Estradiol SCHEMBL4071 1.00 ESR1 (1.00) ESR1CYP3A4ESR2NR3C1PGR
Ethinyl Estradiol SCHEMBL12180049 1.00 ESR1 (1.00) ESR1CYP3A4ESR2NR3C1PGR
Ethinyl Estradiol SCHEMBL16070988 1.00 ESR1 (1.00) ESR1CYP3A4ESR2NR3C1PGR
Ethinyl Estradiol SCHEMBL5030184 1.00 ESR1 (1.00) ESR1CYP3A4ESR2NR3C1PGR
Ethinyl Estradiol SCHEMBL19963467 1.00 ESR1 (1.00) ESR1CYP3A4ESR2NR3C1PGR
Ethinyl Estradiol SCHEMBL14380029 1.00 ESR1 (1.00) ESR1CYP3A4ESR2NR3C1PGR
Ethinyl Estradiol SCHEMBL7602883 1.00 ESR1 (1.00) ESR1CYP3A4ESR2NR3C1PGR
Ethinyl Estradiol SCHEMBL5995835 1.00 ESR1 (1.00) ESR1CYP3A4ESR2NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020081329-A1 METHODS AND COMPOSITIONS FOR MODULATING PCSK9 AND ANGPTL3 EXPRESSION CAMP4 THERAPEUTICS CORPORATION (US) 2020-04-23 WO claimed
EP-1622567-B1 ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF MERCK SHARP & DOHME (US) 2013-07-24 EP claimed
WO-2020081329-A1 METHODS AND COMPOSITIONS FOR MODULATING PCSK9 AND ANGPTL3 EXPRESSION CAMP4 THERAPEUTICS CORPORATION (US) 2020-04-23 WO disclosed
WO-2018032114-A1 NANOCOMPOSITE HYDROGELS AND METHODS OF USING SAME IN PURIFYING A FLUID THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2018-02-22 WO disclosed
CN-107406283-A Water purification process OMYA国际股份公司 2017-11-28 CN disclosed
CN-105209396-B Surface treated calcium carbonate and phyllosilicate and its purposes in water purifying OMYA国际股份公司 2017-09-12 CN disclosed
CN-106632571-A Receptor molecularly-targeted imaging agent and preparation method and application thereof 厦门大学 2017-05-10 CN disclosed
CN-105209396-A Surface-treated calcium carbonate and phyllosilicate and its use in water purification OMYA INT AG 2015-12-30 CN disclosed
CN-105188696-A Gamma-diketones as WNT/beta -catenin signaling pathway activators SAMUMED LLC 2015-12-23 CN disclosed
US-9023818-B2 Pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use GLYCON LLC (US) 2015-05-05 US disclosed
CN-103961337-A COMPOSITION FOR PERCUTANEOUS ADMINISTRATION NOVARTIS AG 2014-08-06 CN disclosed
EP-1093361-A1 PLASTER WHICH CONTAINS STEROIDS, AND A METHOD FOR THE PRODUCTION AND USE THEREOF LTS LOHMANN THERAPIE-SYSTEME GmbH & CO.KG (DE) 2001-04-25 EP disclosed
WO-2000002540-A1 PLASTER WHICH CONTAINS STEROIDS, AND A METHOD FOR THE PRODUCTION AND USE THEREOF LTS LOHMANN THERAPIE-SYSTEME AG (DE) 2000-01-20 WO disclosed
EP-0695177-B1 ACTIVE SUBSTANCE-CONTAINING PLASTER HEXAL AG (DE) 1998-02-18 EP disclosed
EP-0813865-A1 Drug patch HEXAL AG (DE) 1997-12-29 EP disclosed
US-5683711-A TRANSDERMAL DRUG DELIVERY OF ESTROGEN HORMONES HEXAL PHARMA GMBH (DE) 1997-11-04 US disclosed
US-5024998-A Administering in aqueous solution with cyclodextrin derivative UNIVERSITY OF FLORIDA (US) 1991-06-18 US disclosed
US-4983586-A Decreasing precipitation at injection site or in lungs or other organs by combining with hydroxypropyl-beta-cyclodextrin UNIVERSITY OF FLORIDA (US) 1991-01-08 US disclosed
EP-0130067-B1 NOVEL INDOLE DERIVATIVE, PROCESSES FOR ITS PREPARATION AND ITS USE AS FERTILITY CONTROL AGENT Kong, Yun Cheung, Dr. (HK) 1989-09-13 EP disclosed
EP-0130067-A2 Novel indole derivative, processes for its preparation and its use as fertility control agent Kong, Yun Cheung, Dr. (HK) 1985-01-02 EP disclosed