Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethinyl Estradiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 8/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 3/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 3/20 | 1.00 |
| ▸ | PGR | P06401 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | SLC22A2 | O15244 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | SHBG | P04278 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | AR | P10275 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
| ▸ | CYP2B6 | P20813 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | UGT1A1 | P22309 | 1/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethinyl Estradiol SCHEMBL15213118 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL13575761 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL2389175 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL12180049 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL16070988 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL5030184 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL19963467 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL14380029 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL7602883 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL5995835 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 45304 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4744663-A2 | SKIN COMPOSITION | Eaderm Co., Ltd. (JP) | 2026-05-20 | — | — | EP | claimed |
| US-12604896-B2 | Mixture of levonogestrel and ethinylestradiol as control for bark insects | NORIEGA VACA ALFREDO ALEJANDRO (MX) | 2026-04-21 | — | — | US | claimed |
| US-20260102408-A1 | CONTRACEPTIVE COMPOSITIONS WITH REDUCED ADVERSE EFFECTS | ESTETRA SRL (BE) | 2026-04-16 | — | — | US | claimed |
| US-20260097039-A1 | METHODS FOR TREATING A FATTY LIVER DISEASE | MADRIGAL PHARMACEUTICALS INC (US) | 2026-04-09 | — | — | US | claimed |
| EP-4719422-A1 | PROGESTOGEN-FREE ORAL DOSAGE UNIT FOR USE IN FEMALE CONTRACEPTION AND TREATMENT OF ENDOMETRIOSIS | Pandora Endocrine Innovation B.V. (NL) | 2026-04-08 | — | — | EP | claimed |
| US-20260091041-A1 | Methods of Treating Heavy Menstrual Bleeding | ABBVIE INC (US) | 2026-04-02 | — | — | US | claimed |
| US-20260076896-A1 | CONTINUOUS OR PERIODICAL TRANSDERMAL DELIVERY OF EXOGENOUS MOLECULE | KIFFIK BIOMEDICAL INC (US) | 2026-03-19 | — | — | US | claimed |
| EP-4711364-A1 | FUSED PYRROLE RING OR FUSED PYRIDINE RING COMPOUND | Pharmaengine, Inc. (TW) | 2026-03-18 | — | — | EP | claimed |
| EP-4701737-A2 | MTA-COOPERATIVE PRMT5 INHIBITOR | Pharmaengine, Inc. (TW) | 2026-03-04 | — | — | EP | claimed |
| CN-121586586-A | Process for preparing ophthalmic compositions of low solubility materials | 全福生物科技股份有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-4027019-A | 3-Oximes of D-17α-ethynyl-19-nortestosterone esters and method | ORTHO PHARMACEUTICAL CORPORATION (US) | 1977-05-31 | — | — | US | claimed |
| US-4016251-A | Vaginal drug dispensing device | ALZA CORPORATION (US) | 1977-04-05 | — | — | US | claimed |
| US-4014987-A | VAGINAL DEVICE; USING A HYDROPHOBIC POLYCARBOXYLIC ACID AS DRUG RELEASE RATE CONTROLLER | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |
| US-4009266-A | METHOD OF TREATMENT OF NEMATODE PARASITE INFECTIONS IN DOMESTIC ANIMALS | AYALEW LIYEW | 1977-02-22 | — | — | US | claimed |
| US-3993072-A | Microporous drug delivery device | ALZA CORPORATION (US) | 1976-11-23 | — | — | US | claimed |
| US-3969502-A | 17-ALPHA ETHYNYLESTRADIOL AND NORGESTREL OR 17-ETHYNYL-19-NORTESTERONE ACETATE | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-07-13 | — | — | US | claimed |
| US-3946106-A | POLYSILOXANES | G. D. SEARLE & CO. (US) | 1976-03-23 | — | — | US | claimed |
| US-3942641-A | Dispensing packages containing novel cyclic progestogen-interrupted estrogen oral contraceptive regimens | SYNTEX CORPORATION (PM) | 1976-03-09 | — | — | US | claimed |
| US-3939186-A | Process for producing ethers of steroids | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1976-02-17 | — | — | US | claimed |
| US-3932635-A | Novel cyclic progestogen-interrupted estrogen oral contraceptive regimens | SYNTEX CORPORATION (PM) | 1976-01-13 | — | — | US | claimed |