Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethinyl Estradiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 8/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 3/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 3/20 | 1.00 |
| ▸ | PGR | P06401 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | SLC22A2 | O15244 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | SHBG | P04278 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | AR | P10275 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
| ▸ | CYP2B6 | P20813 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | UGT1A1 | P22309 | 1/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethinyl Estradiol SCHEMBL15213118 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL13575761 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL4071 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL2389175 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL12180049 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL16070988 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL5030184 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL19963467 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL14380029 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR | |
| Ethinyl Estradiol SCHEMBL5995835 | 1.00 | ESR1 (1.00) | ESR1CYP3A4ESR2NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114720570-B | Method for detecting 8 estrogens in fish meat | 上海市环境科学研究院 | 2023-08-29 | — | — | CN | disclosed |
| CN-114720570-A | Method for detecting 8 estrogens in fish | 上海市环境科学研究院 | 2022-07-08 | — | — | CN | disclosed |
| EP-2899281-B1 | Inhibitors of sterol metabolism for their use to accumulate triglycerides in microalgae, and methods thereof | COMMISSARIAT ENERGIE ATOMIQUE (FR) | 2020-07-01 | — | — | EP | disclosed |
| US-9107959-B2 | Method for site-specific polyvalent display on polymers | NEW YORK UNIVERSITY (US) | 2015-08-18 | — | — | US | disclosed |
| US-9107959-B2 | Method for site-specific polyvalent display on polymers | NEW YORK UNIVERSITY (US) | 2015-08-18 | — | — | US | disclosed |
| US-8524663-B2 | Method for site-specific polyvalent display on polymers | NEW YORK UNIVERSITY (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524663-B2 | Method for site-specific polyvalent display on polymers | NEW YORK UNIVERSITY (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120122779-A1 | Method for site-specific polyvalent display on polymers | NEW YORK UNIVERSITY | 2012-05-17 | — | — | US | disclosed |
| US-20120122779-A1 | Method for site-specific polyvalent display on polymers | NEW YORK UNIVERSITY | 2012-05-17 | — | — | US | disclosed |
| US-20080269425-A1 | Novel Catalyst | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2008-10-30 | — | — | US | disclosed |
| US-20080269425-A1 | Novel Catalyst | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2008-10-30 | — | — | US | disclosed |
| EP-1829610-A1 | NOVEL CATALYST | Wako Pure Chemical Industries, Ltd. (JP) | 2007-09-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269425-A1 | Novel Catalyst | PPOX, PNMT, POLRMT | ESR1 2244/4885CYP3A4 388/4885ESR2 2822/4885 |
| US-20120122779-A1 | Method for site-specific polyvalent display on polymers | NGLY1, DNPEP, GPKOW | ESR1 4503/4885CYP3A4 3957/4885ESR2 4764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.