Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 10/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 4/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 2/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892392 | 0.82 | PRMT5 (0.51) | PRMT5WDR77METTL3 | |
| SCHEMBL23892274 | 0.82 | PRMT5 (0.44) | PRMT5WDR77METTL3PDE3BPDE3A | |
| SCHEMBL23892500 | 0.79 | PRMT5 (0.36) | PRMT5WDR77PDPK1METTL3 | |
| SCHEMBL18571908 | 0.77 | METTL3 (0.39) | PRMT5WDR77PDPK1METTL3 | |
| SCHEMBL23892503 | 0.76 | METTL3 (0.36) | PRMT5WDR77PDPK1METTL3 | |
| SCHEMBL23892558 | 0.76 | METTL3 (0.40) | PRMT5WDR77METTL3 | |
| SCHEMBL23892364 | 0.76 | PRMT5 (0.37) | PRMT5WDR77PDPK1METTL3 | |
| SCHEMBL23892285 | 0.76 | PRMT5 (0.38) | PRMT5WDR77PDPK1METTL3 | |
| SCHEMBL23892556 | 0.76 | PRMT5 (0.37) | PRMT5WDR77PDPK1METTL3 | |
| SCHEMBL23892212 | 0.76 | PRMT5 (0.37) | PRMT5WDR77PDPK1METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |