Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 9/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.35 |
| ▸ | NNMT | P40261 | 2/20 | 0.32 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892650 | 0.89 | PRMT5 (0.46) | PRMT5WDR77METTL3 | |
| SCHEMBL25951705 | 0.89 | PRMT5 (0.46) | PRMT5WDR77METTL3 | |
| SCHEMBL23892251 | 0.83 | KDM4E (0.37) | PRMT5WDR77BCHE | |
| SCHEMBL18571902 | 0.82 | PRMT5 (0.40) | PRMT5WDR77NNMTMETTL3 | |
| SCHEMBL23892599 | 0.82 | PRMT5 (0.45) | PRMT5WDR77METTL3PDE10A | |
| SCHEMBL23892477 | 0.80 | PRMT5 (0.34) | PRMT5WDR77BCHE | |
| SCHEMBL18572842 | 0.78 | PRMT5 (0.36) | PRMT5WDR77NNMTMETTL3 | |
| SCHEMBL23892347 | 0.78 | PRMT5 (0.40) | PRMT5WDR77METTL3 | |
| SCHEMBL23892258 | 0.78 | GRM2 (0.36) | PRMT5WDR77NNMTBCHE | |
| SCHEMBL23892261 | 0.78 | METAP2 (0.40) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |