Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.47 |
| ▸ | UBA6 | A0AVT1 | 4/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.38 |
| ▸ | NNMT | P40261 | 4/20 | 0.38 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16769947 | 0.91 | PRMT5 (0.44) | PRMT5WDR77UBA6SLC22A12PIP4K2A | |
| SCHEMBL1795549 | 0.89 | PRMT5 (0.45) | PRMT5WDR77UBA6NNMT | |
| SCHEMBL1947419 | 0.88 | UBA6 (0.41) | PRMT5WDR77UBA6NNMTNAE1 | |
| SCHEMBL936138 | 0.88 | UBA6 (0.41) | PRMT5WDR77UBA6NNMTNAE1 | |
| SCHEMBL18589317 | 0.88 | UBA6 (0.41) | PRMT5WDR77UBA6NNMTNAE1 | |
| SCHEMBL1795550 | 0.86 | UBA6 (0.40) | PRMT5WDR77UBA6NNMTNAE1 | |
| SCHEMBL18571707 | 0.84 | ABL1 (0.44) | PRMT5WDR77UBA6SLC22A12PIP4K2A | |
| SCHEMBL16967987 | 0.84 | PIP4K2A (0.49) | PRMT5WDR77SLC22A12PIP4K2A | |
| SCHEMBL1442965 | 0.84 | PIP4K2A (0.45) | PRMT5WDR77UBA6SLC22A12PIP4K2A | |
| SCHEMBL15636715 | 0.84 | PIP4K2A (0.45) | PRMT5WDR77UBA6SLC22A12PIP4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |