Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.41 |
| ▸ | ABL1 | P00519 | 9/20 | 0.41 |
| ▸ | ABL2 | P42684 | 9/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 5/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25955833 | 0.92 | SRC (0.40) | SRCABL1ABL2EGFRERBB2 | |
| SCHEMBL23892454 | 0.85 | PRMT5 (0.46) | PRMT5WDR77METTL3 | |
| SCHEMBL25955837 | 0.85 | PRMT5 (0.42) | PRMT5WDR77METTL3 | |
| SCHEMBL23892564 | 0.85 | EPHA2 (0.39) | EGFRERBB2PRMT5WDR77METTL3 | |
| SCHEMBL23892623 | 0.85 | EPHA2 (0.39) | EGFRERBB2PRMT5WDR77METTL3 | |
| SCHEMBL23892504 | 0.84 | SRC (0.41) | SRCABL1ABL2EGFRERBB2 | |
| SCHEMBL18571823 | 0.82 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL18572869 | 0.80 | PRMT5 (0.43) | PRMT5WDR77METTL3 | |
| SCHEMBL22684768 | 0.79 | PRMT5 (0.45) | PRMT5WDR77METTL3 | |
| SCHEMBL23892641 | 0.79 | PRMT5 (0.47) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |