Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 17/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | METTL3 | Q86U44 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892412 | 0.93 | PRMT5 (0.41) | PRMT5WDR77ADKMETTL3 | |
| SCHEMBL18571823 | 0.86 | PRMT5 (0.54) | PRMT5WDR77ADKMETTL3 | |
| SCHEMBL23892689 | 0.85 | SRC (0.41) | PRMT5WDR77METTL3 | |
| SCHEMBL18572869 | 0.81 | PRMT5 (0.43) | PRMT5WDR77ADKMETTL3 | |
| SCHEMBL18571815 | 0.79 | PRMT5 (0.53) | PRMT5WDR77ADKMETTL3 | |
| SCHEMBL25955833 | 0.78 | SRC (0.40) | — | |
| SCHEMBL25952132 | 0.76 | PRMT5 (0.44) | PRMT5WDR77METTL3 | |
| SCHEMBL18572864 | 0.74 | PRMT5 (0.42) | PRMT5WDR77METTL3 | |
| SCHEMBL20419288 | 0.73 | ADK (0.58) | PRMT5WDR77ADKMETTL3 | |
| SCHEMBL23982356 | 0.73 | ADK (0.58) | PRMT5WDR77ADKMETTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |