Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | DBH | P09172 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21019816 | 0.89 | MAPT (0.41) | PKMMAPTGRK2P2RX7TDP1 | |
| SCHEMBL23897356 | 0.78 | GRK2 (0.43) | MAPTGRK2P2RX7TDP1DBH | |
| SCHEMBL29976343 | 0.76 | SMN1; SMN2 (0.33) | PKMMAPTGRK2P2RX7TDP1 | |
| SCHEMBL19806011 | 0.76 | SMN1; SMN2 (0.33) | PKMMAPTGRK2P2RX7TDP1 | |
| SCHEMBL20985635 | 0.75 | SDHB (0.33) | PKMMAPTGRK2P2RX7TDP1 | |
| SCHEMBL21020624 | 0.70 | GRK2 (0.43) | GRK2P2RX7DBHSMN1; SMN2ROCK2 | |
| SCHEMBL19806006 | 0.69 | DBH (0.50) | PKMMAPTGRK2P2RX7TDP1 | |
| SCHEMBL19806008 | 0.69 | DBH (0.47) | MAPTGRK2TDP1DBHSMN1; SMN2 | |
| SCHEMBL26313233 | 0.66 | SDHB (0.49) | MAPTGRK2TDP1DBHROCK2 | |
| SCHEMBL19806089 | 0.64 | SDHB (0.49) | MAPTSMN1; SMN2ALDH1A1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-20210309647-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11725000-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | PKM 716/4885MAPT 2304/4885GRK2 3248/4885 |
| US-20210309647-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | PKM 716/4885MAPT 2304/4885GRK2 3248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.