Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 7/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30612395 | 0.86 | KDM4E (0.52) | TYK2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL30509877 | 0.84 | MEN1 (0.53) | TYK2MEN1KMT2AKDM4EPARP1 | |
| Hydrochloric Acid SCHEMBL11452778 | 0.84 | KDM4E (0.51) | TYK2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL11452777 | 0.84 | KDM4E (0.42) | TYK2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL30612380 | 0.84 | KDM4E (0.47) | TYK2ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL22498188 | 0.81 | KDM4E (0.47) | ALDH1A1MEN1KMT2AKDM4EPARP1 | |
| SCHEMBL13101590 | 0.80 | ALDH1A1 (0.47) | TYK2ALDH1A1MEN1KMT2ACNR1 | |
| SCHEMBL12923010 | 0.80 | CNR2 (0.60) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL21246071 | 0.79 | KDM4E (0.43) | ALDH1A1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL12923027 | 0.79 | SMN1; SMN2 (0.53) | ALDH1A1MEN1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021198709-A1 | NAPHTHYRIDINE COMPOUNDS AS INHIBITORS OF MER TYROSINE KINASE AND AXL TYROSINE KINASE | KINSENSUS LIMITED (GB) | 2021-10-07 | — | — | WO | disclosed |