Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3783697 | 0.87 | CA12 (0.48) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL23899064 | 0.86 | MAPT (0.60) | GRM4MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL23898949 | 0.85 | POLB (0.48) | MAPTALDH1A1POLBSMN1; SMN2RAB9A | |
| SCHEMBL23898952 | 0.82 | GRM4 (0.49) | GRM4MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL21661825 | 0.82 | KLK7 (0.56) | MAPTALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL6815538 | 0.79 | CYP17A1 (0.49) | GRM4MAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL23899098 | 0.79 | ALDH1A1 (0.53) | GRM4MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL23899107 | 0.78 | KLK7 (0.54) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL23899174 | 0.78 | MEN1 (0.54) | GRM4MEN1KMT2AALDH1A1POLB | |
| SCHEMBL6056066 | 0.77 | RAB9A (0.54) | MEN1KMT2AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309630-A1 | ALLOSTERIC INHIBITOR OF WEE1 KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309630-A1 | ALLOSTERIC INHIBITOR OF WEE1 KINASE | WEE1, WEE2, PAXBP1 | GRM4 3821/4885MEN1 2076/4885KMT2A 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.