Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 11/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAP3K14 | Q99558 | 7/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23900349 | 0.88 | RIPK1 (0.48) | RIPK1GRM5MAP3K14 | |
| Hydrochloric Acid SCHEMBL30250543 | 0.81 | MAP3K14 (0.40) | RIPK1MAP3K14PIK3CDPIK3R1CHRNB2 | |
| SCHEMBL23081922 | 0.79 | MAP3K14 (0.49) | RIPK1MAP3K14PIK3CDPIK3R1 | |
| SCHEMBL23900311 | 0.76 | GRM5 (0.51) | RIPK1GRM5 | |
| SCHEMBL22590505 | 0.76 | MAP3K14 (0.57) | RIPK1MAP3K14PIK3CDPIK3R1 | |
| SCHEMBL23900266 | 0.76 | RIPK1 (0.49) | RIPK1GRM5PIK3CDPIK3R1 | |
| SCHEMBL23900227 | 0.75 | RIPK1 (0.45) | RIPK1MAP3K14PIK3CDPIK3R1 | |
| SCHEMBL25077692 | 0.72 | RIPK1 (0.47) | RIPK1MAP3K14 | |
| SCHEMBL25077491 | 0.70 | MAP3K14 (0.50) | MAP3K14 | |
| SCHEMBL23081610 | 0.67 | RIPK1 (0.46) | RIPK1GRM5MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021203011-A1 | RIP1K INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2021-10-07 | — | — | WO | disclosed |