Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23081899 | 0.83 | RIPK1 (0.49) | GRM5RIPK1NPC1HCRTR1RAB9A | |
| SCHEMBL25586388 | 0.81 | NPC1 (0.49) | GRM5RIPK1NPC1HCRTR1RAB9A | |
| SCHEMBL23900235 | 0.76 | RIPK1 (0.46) | GRM5RIPK1 | |
| SCHEMBL23900349 | 0.74 | RIPK1 (0.48) | GRM5RIPK1 | |
| SCHEMBL23900266 | 0.73 | RIPK1 (0.49) | GRM5RIPK1 | |
| SCHEMBL30250877 | 0.73 | RIPK1 (0.39) | RIPK1 | |
| SCHEMBL21500799 | 0.73 | RIPK1 (0.39) | RIPK1 | |
| SCHEMBL23075920 | 0.67 | RIPK1 (0.48) | GRM5RIPK1 | |
| SCHEMBL23081632 | 0.67 | CYP11B1 (0.51) | GRM5RIPK1 | |
| SCHEMBL23081600 | 0.67 | RIPK1 (0.49) | GRM5RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021203011-A1 | RIP1K INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2021-10-07 | — | — | WO | disclosed |