Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 19/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 19/20 | 0.52 |
| ▸ | IGF1R | P08069 | 14/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | GRK5 | P34947 | 2/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.48 |
| ▸ | MST1R | Q04912 | 2/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23901345 | 0.85 | ALK (0.71) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL23901334 | 0.84 | INSR (0.73) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL31391720 | 0.84 | INSR (0.66) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL31391723 | 0.84 | INSR (0.73) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL28999405 | 0.84 | INSR (0.66) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL23901394 | 0.83 | INSR (0.70) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL23901169 | 0.83 | INSR (0.76) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL23901261 | 0.82 | INSR (0.61) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL31391722 | 0.82 | INSR (0.61) | INSRALKIGF1RAURKAAURKB | |
| SCHEMBL23901186 | 0.82 | INSR (0.63) | INSRALKIGF1RAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916771-A | Multi-target antitumor compound and preparation method and application thereof | 浙江华海药业股份有限公司 | 2023-04-04 | — | — | CN | claimed |
| CN-115916771-A | Multi-target antitumor compound and preparation method and application thereof | 浙江华海药业股份有限公司 | 2023-04-04 | — | — | CN | disclosed |
| WO-2021197467-A1 | MULTI-TARGET ANTI-TUMOR COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海华汇拓医药科技有限公司 | 2021-10-07 | — | — | WO | disclosed |