SCHEMBL239028

SCHEMBL239028

Nc1cc(F)c(N2CCC(Cc3ccccc3)CC2)c(F)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRMT3 O60678 1/20 0.52
▸ CARM1 Q86X55 1/20 0.52
▸ PRMT6 Q96LA8 1/20 0.52
▸ PRMT1 Q99873 1/20 0.52
▸ PRMT8 Q9NR22 1/20 0.52
▸ ATM Q13315 2/20 0.51
▸ MEN1 O00255 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ CCR3 P51677 2/20 0.49
▸ CYP2C9 P11712 1/20 0.48
▸ CYP2C19 P33261 1/20 0.48
▸ MAPK14 Q16539 1/20 0.48
▸ GPR84 Q9NQS5 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ MAPT P10636 1/20 0.46
▸ HTT P42858 1/20 0.46
▸ GFER P55789 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ SLC6A2 P23975 1/20 0.45
▸ SLC6A4 P31645 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL242034 0.84 SLC18A3 (0.47) CCR3SLC6A4
SCHEMBL236849 0.78 DHFR (0.46) CYP2C9TSHRMAPTGFER
SCHEMBL25031021 0.77 FFAR4 (0.40) —
SCHEMBL28855647 0.77 FFAR4 (0.38) —
SCHEMBL25194061 0.77 FFAR4 (0.39) —
SCHEMBL6429226 0.77 SLC6A2 (0.56) PRMT3CARM1PRMT6PRMT1PRMT8
SCHEMBL6427944 0.76 MEN1 (0.61) PRMT3CARM1PRMT6PRMT1PRMT8
SCHEMBL27098837 0.75 FFAR4 (0.41) —
SCHEMBL6636349 0.74 CCR3 (0.65) PRMT3CARM1PRMT6PRMT1PRMT8
SCHEMBL240318 0.74 SSTR2 (0.38) MEN1KMT2AMAPTHTTGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285378-A1 Anti-Viral Compounds ABBVIE INC. (US) 2023-09-14 — — US disclosed
EP-3438106-A1 ANTI-VIRAL COMPOUNDS AbbVie Ireland Unlimited Company (IE) 2019-02-06 — — EP disclosed
US-20190015402-A1 Anti-Viral Compounds ABBVIE INC. (US) 2019-01-17 — — US disclosed
US-10039754-B2 Anti-viral compounds ABBVIE INC. (US) 2018-08-07 — — US disclosed
US-10028937-B2 Anti-viral compounds ABBVIE INC. (US) 2018-07-24 — — US disclosed
US-20170157105-A1 Anti-Viral Compounds ABBVIE INC. (US) 2017-06-08 — — US disclosed
US-20170157104-A1 Anti-Viral Compounds ABBVIE INC. (US) 2017-06-08 — — US disclosed
EP-2678334-B1 ANTI-VIRAL COMPOUNDS ABBVIE BAHAMAS LTD (BS) 2017-03-22 — — EP disclosed
US-9586978-B2 Anti-viral compounds ABBVIE INC. (US) 2017-03-07 — — US disclosed
EP-2692346-B1 An antiviral 1-phenyl-2,5-dibenzimidazol-5-yl-pyrrolidine derivative ABBVIE BAHAMAS LTD (BS) 2015-12-02 — — EP disclosed
US-8921514-B2 Anti-viral compounds ABBVIE INC. (US) 2014-12-30 — — US disclosed
EP-2692346-A1 An antiviral 1-phenyl-2,5-dibenzimidazol-5-yl-pyrrolidine derivative Abbvie Inc. (US) 2014-02-05 — — EP disclosed
EP-2692726-A1 Anti-viral compounds Abbvie Inc. (US) 2014-02-05 — — EP disclosed
EP-2678334-A1 ANTI-VIRAL COMPOUNDS Abbvie Inc. (US) 2014-01-01 — — EP disclosed
EP-2627651-A1 ANTI-VIRAL COMPOUNDS Abbvie Inc. (US) 2013-08-21 — — EP disclosed
WO-2012116257-A1 ANTI-VIRAL COMPOUNDS ABBVIE INC. (US) 2012-08-30 — — WO disclosed
US-20120220562-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-08-30 — — US disclosed
WO-2012051361-A1 ANTI-VIRAL COMPOUNDS ABBOTT LABORATORIES (US) 2012-04-19 — — WO disclosed
US-20120004196-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-01-05 — — US disclosed
US-20110207699-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2011-08-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10028937-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS PRMT3 1926/4885CARM1 3322/4885PRMT6 2312/4885
US-20230285378-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PRMT3 1926/4885CARM1 3322/4885PRMT6 2312/4885
US-20120220562-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PRMT3 1926/4885CARM1 3322/4885PRMT6 2312/4885
US-20170157105-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PRMT3 1926/4885CARM1 3322/4885PRMT6 2312/4885
US-20170157104-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PRMT3 1926/4885CARM1 3322/4885PRMT6 2312/4885
US-20110207699-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PRMT3 1926/4885CARM1 3322/4885PRMT6 2312/4885
US-20190015402-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PRMT3 1926/4885CARM1 3322/4885PRMT6 2312/4885
US-20120004196-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS PRMT3 1926/4885CARM1 3322/4885PRMT6 2312/4885
US-10039754-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS PRMT3 1926/4885CARM1 3322/4885PRMT6 2312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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