Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 12/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 14/20 | 0.35 |
| ▸ | ABL1 | P00519 | 13/20 | 0.35 |
| ▸ | EGFR | P00533 | 12/20 | 0.35 |
| ▸ | HCK | P08631 | 12/20 | 0.35 |
| ▸ | KDR | P35968 | 12/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.35 |
| ▸ | MTOR | P42345 | 12/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.35 |
| ▸ | PRKDC | P78527 | 12/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23902886 | 0.75 | ADORA2A (0.33) | PI4KBADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL18076608 | 0.63 | NPC1 (0.33) | PI4KBADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL19522164 | 0.59 | ADORA2A (0.50) | PI4KBADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL24670253 | 0.57 | TOP2A (0.38) | TOP2A | |
| SCHEMBL18076633 | 0.57 | AAK1 (0.37) | — | |
| SCHEMBL23902965 | 0.56 | PI4KB (0.39) | PI4KBADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL1914 | 0.55 | ADORA2A (0.41) | ADORA2AADORA1 | |
| SCHEMBL10261918 | 0.55 | SRC (0.66) | PI4KBSRCABL1EGFRHCK | |
| SCHEMBL23869924 | 0.55 | KDR (0.56) | PI4KBADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL12616367 | 0.53 | TOP2A (0.37) | TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309688-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309688-A1 | PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT6 | PI4KB 3092/4885ADORA2A 4256/4885ADORA1 3850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.