Mechlorethamine

Mechlorethamine

SCHEMBL23909362

CN(CCCl)CCCl.ClC(Cl)Cl

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.80
LMNA P02545 2/20 0.75
TP53 P04637 1/20 0.75
TSHR P16473 1/20 0.75
HTT P42858 1/20 0.75
HBB P68871 1/20 0.75
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
CA12 O43570 1/20 0.37
CA2 P00918 1/20 0.37
CA3 P07451 1/20 0.37
CA4 P22748 1/20 0.37
CA6 P23280 1/20 0.37
CA5A P35218 1/20 0.37
CA7 P43166 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
CA5B Q9Y2D0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mechlorethamine SCHEMBL11905424 0.89 MAPT (1.00) MAPTLMNATP53TSHRHTT
Mechlorethamine SCHEMBL3861 0.89
Mechlorethamine SCHEMBL2554459 0.86
Mechlorethamine SCHEMBL3855 0.86
Mechlorethamine SCHEMBL5330778 0.86 LMNA (1.00) MAPTLMNATP53TSHRHTT
Mechlorethamine SCHEMBL10618376 0.86 LMNA (1.00) MAPTLMNATP53TSHRHTT
Mechlorethamine SCHEMBL15532070 0.83
Mechlorethamine SCHEMBL9139106 0.83 LMNA (0.93) MAPTLMNATP53TSHRHTT
Mechlorethamine SCHEMBL12802922 0.83 MAPT (0.86) MAPTLMNATP53TSHRHTT
SCHEMBL10324777 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11752165-B2 Basic chemotherapeutic intratumour injection formulation US Nano Food & Drug, Inc (US) 2023-09-12 US disclosed
EP-4135686-A1 BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION US Nano Food & Drug Inc (US) 2023-02-22 EP disclosed
WO-2021211294-A1 BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION US Nano Food & Drug INC (US) 2021-10-21 WO disclosed
US-20210315913-A1 BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION US Nano Food & Drug, Inc (US) 2021-10-14 US disclosed