SCHEMBL23909400

SCHEMBL23909400

CCNc1ncnc(N(CC)CC)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.44
GAA P10253 2/20 0.43
CYP1A2 P05177 2/20 0.43
CYP2C19 P33261 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
ALDH1A1 P00352 6/20 0.39
CREBBP Q92793 2/20 0.39
CA1 P00915 3/20 0.37
CA2 P00918 3/20 0.37
CA9 Q16790 3/20 0.37
POLB P06746 1/20 0.37
LMNA P02545 2/20 0.35
TDP1 Q9NUW8 1/20 0.35
RAB9A P51151 1/20 0.35
USP2 O75604 1/20 0.34
GLA P06280 1/20 0.34
HPGD P15428 1/20 0.34
CASP1 P29466 1/20 0.34
CASP7 P55210 1/20 0.34
HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8433668 0.83 CA1 (0.37) KDM4EALDH1A1CA1CA2CA9
SCHEMBL9616612 0.81 MEN1 (0.40) KDM4EGAACYP1A2CYP2C19L3MBTL1
SCHEMBL8383420 0.81 TDP1 (0.38) KDM4ECYP1A2CYP2C19ALDH1A1CA1
SCHEMBL893013 0.80 TDP1 (0.46) CYP1A2L3MBTL1ALDH1A1CA1CA2
SCHEMBL6978430 0.80 LMNA (0.52) KDM4EGAACYP1A2CYP2C19L3MBTL1
SCHEMBL761988 0.78 GAA (0.61) KDM4EGAACYP1A2CYP2C19L3MBTL1
SCHEMBL6716129 0.78 GAA (0.61) KDM4EGAACYP1A2CYP2C19L3MBTL1
SCHEMBL762576 0.78 GAA (0.55) KDM4EGAACYP1A2CYP2C19L3MBTL1
SCHEMBL9490215 0.75 CA1 (0.34) GAAALDH1A1CA1CA2CA9
SCHEMBL11793081 0.75 LMNA (0.54) KDM4EGAACYP1A2CYP2C19L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4291571-A2 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN Seattle Children's Hospital d/b/a Seattle Children's Research Institute (US) 2023-12-20 EP disclosed
US-20230172981-A1 METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST (US) 2023-06-08 US disclosed
WO-2022174035-A2 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2022-08-18 WO disclosed
US-20210317407-A1 METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS Seattle Children's Hospital (dba Seattle Children's Research Institute) 2021-10-14 US disclosed