Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307214 | 0.84 | AGTR2 (0.43) | AGTR2GAAMAPTPKMPOLQ | |
| SCHEMBL18256941 | 0.83 | AGTR2 (0.38) | AGTR2GAAMAPTPKMPIK3CA | |
| SCHEMBL22265647 | 0.83 | GAA (0.39) | AGTR2GAAMAPTPKMPIK3CA | |
| SCHEMBL18542859 | 0.80 | NOTUM (0.37) | AGTR2TSHRGAAMAPTPKM | |
| SCHEMBL14873216 | 0.80 | AGTR2 (0.36) | AGTR2GAAMAPTPKMPOLQ | |
| SCHEMBL14817541 | 0.77 | CYP3A4 (0.35) | AGTR2GAAMAPTPKMPOLQ | |
| SCHEMBL13927587 | 0.77 | KMT2A (0.40) | AGTR2TSHRGAAALDH1A1POLB | |
| SCHEMBL13620068 | 0.77 | AGTR2 (0.37) | AGTR2TSHRPOLQSMN1; SMN2ALDH1A1 | |
| SCHEMBL30937116 | 0.74 | GAA (0.37) | AGTR2GAAMAPTPKMPIK3CA | |
| SCHEMBL22766292 | 0.74 | ALDH1A1 (0.41) | TSHRGAAMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593090-B1 | C-MET MODULATOR PHARMACEUTICAL COMPOSITIONS | EXELIXIS INC (US) | 2021-10-13 | — | — | EP | disclosed |