Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 5/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.42 |
| ▸ | RARA | P10276 | 2/20 | 0.40 |
| ▸ | RARB | P10826 | 2/20 | 0.40 |
| ▸ | RARG | P13631 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
| ▸ | GOT1 | P17174 | 1/20 | 0.40 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391841 | 0.93 | HDAC11 (0.42) | PSEN1ALOX5HDAC11RARARARB | |
| SCHEMBL2387856 | 0.90 | RARA (0.49) | PSEN1ALOX5HDAC11RARARARB | |
| SCHEMBL2394235 | 0.87 | HDAC11 (0.42) | HDAC11RARARARBRARGLMNA | |
| SCHEMBL2391032 | 0.87 | HDAC11 (0.46) | PSEN1ALOX5HDAC11RARARARB | |
| SCHEMBL2395834 | 0.86 | PTPN11 (0.48) | HDAC11RARARARBRARGLMNA | |
| SCHEMBL2390953 | 0.85 | PSEN1 (0.37) | PSEN1ALOX5HDAC11RARARARB | |
| SCHEMBL2393218 | 0.85 | S1PR1 (0.41) | PSEN1ALOX5HDAC11RARARARB | |
| SCHEMBL2393669 | 0.84 | HDAC11 (0.42) | PSEN1ALOX5HDAC11RARARARB | |
| SCHEMBL6022589 | 0.84 | HDAC11 (0.55) | HDAC11RARARARBRARGLMNA | |
| SCHEMBL6022597 | 0.84 | HDAC11 (0.55) | HDAC11RARARARBRARGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |