Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 9/20 | 0.77 |
| ▸ | NR0B2 | Q15466 | 3/20 | 0.77 |
| ▸ | RARB | P10826 | 5/20 | 0.74 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | RARA | P10276 | 2/20 | 0.55 |
| ▸ | RARG | P13631 | 2/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | PTPRCAP | Q14761 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391213 | 1.00 | PTPN11 (0.77) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL2389152 | 0.89 | RARB (0.80) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL2389155 | 0.89 | RARB (0.80) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL29604865 | 0.87 | PTPN11 (1.00) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL2407028 | 0.87 | PTPN11 (0.77) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL1914215 | 0.87 | PTPN11 (1.00) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL1914213 | 0.87 | PTPN11 (1.00) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL2407027 | 0.87 | PTPN11 (0.77) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL2391569 | 0.87 | PTPN11 (0.60) | PTPN11NR0B2RARBHDAC11HDAC3 | |
| SCHEMBL2390934 | 0.87 | RARB (0.73) | PTPN11NR0B2RARBHDAC11HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |
| US-7449495-B2 | Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-11-11 | — | — | US | disclosed |
| US-20080021088-A1 | Retinoid Derivatives With Antiangiogenic, Antitumoral And Proapoptotic Activities | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-01-24 | — | — | US | disclosed |
| US-7053071-B2 | For therapy of leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells | THE BURNHAM INSTITUTE (US) | 2006-05-30 | — | — | US | disclosed |
| EP-1456165-A1 | INDUCTION OF APOPTOSIS IN CANCER CELLS | The Burnham Institute (US) | 2004-09-15 | — | — | EP | disclosed |
| US-20030176506-A1 | Induction of apoptosis in cancer cells | BURNHAM INSTITUTE FOR MEDICAL RESEARCH | 2003-09-18 | — | — | US | disclosed |
| WO-2003048101-A1 | INDUCTION OF APOPTOSIS IN CANCER CELLS | THE BURNHAM INSTITUTE (US) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021088-A1 | Retinoid Derivatives With Antiangiogenic, Antitumoral And Proapoptotic Activities | RARA, RARB, RXRA | PTPN11 2829/4885NR0B2 89/4885RARB 2/4885 |
| US-20030176506-A1 | Induction of apoptosis in cancer cells | MCL1, BAD, BCL2 | PTPN11 2842/4885NR0B2 2377/4885RARB 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.