SCHEMBL23912343

SCHEMBL23912343

COC(=O)c1ccc(CCCC(=O)OC(C)(C)C)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4A11 Q02928 2/20 0.60
CYP4F2 P78329 1/20 0.59
LOXL2 Q9Y4K0 1/20 0.49
HSD17B10 Q99714 2/20 0.45
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
ALDH1A1 P00352 1/20 0.45
TP53 P04637 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
HPGD P15428 1/20 0.45
ALOX15 P16050 1/20 0.45
ALOX12 P18054 1/20 0.45
CYP2C19 P33261 1/20 0.45
CKS1B P61024 1/20 0.45
SKP2 Q13309 1/20 0.45
HIF1A Q16665 1/20 0.45
HDAC1 Q13547 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12680354 0.91 CYP4A11 (0.55) CYP4A11CYP4F2LOXL2HSD17B10CA1
SCHEMBL8997287 0.84 CYP4A11 (0.54) CYP4A11CYP4F2LOXL2CA1CA2
SCHEMBL4183681 0.83 CYP4A11 (0.52) CYP4A11CYP4F2HSD17B10ALDH1A1HPGD
SCHEMBL1743875 0.83 CYP4A11 (0.52) CYP4A11CYP4F2HSD17B10ALDH1A1HPGD
SCHEMBL2650122 0.81 LOXL2 (0.54) CYP4A11CYP4F2LOXL2CA1CA2
SCHEMBL22167270 0.81 PPARA (0.42) CYP4A11CYP4F2HSD17B10HDAC1HDAC6
SCHEMBL7414163 0.81 FAAH (0.43) HSD17B10ALDH1A1HPGDTDP1GAA
SCHEMBL19078977 0.80 CYP4A11 (0.48) CYP4A11CYP4F2LOXL2HSD17B10CA1
SCHEMBL19078982 0.80 CYP4A11 (0.50) CYP4A11CYP4F2LOXL2HSD17B10ALDH1A1
SCHEMBL7965135 0.80 MAOB (0.42) HSD17B10CA1CA2TDP1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3892278-B1 CYCLOALKANE-1,3-DIAMINE DERIVATIVE DAIICHI SANKYO CO LTD (JP) 2024-02-28 EP disclosed
EP-3892278-A1 CYCLOALKANE-1,3-DIAMINE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2021-10-13 EP disclosed