Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.50 |
| ▸ | SPHK1 | Q9NYA1 | 12/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 10/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726262 | 1.00 | GBA1 (0.50) | GBA1SPHK1GBA2GAASPHK2 | |
| SCHEMBL19512642 | 0.89 | GBA2 (0.53) | GBA1SPHK1GBA2GAASPHK2 | |
| SCHEMBL23517199 | 0.89 | GBA2 (0.53) | GBA1SPHK1GBA2GAASPHK2 | |
| SCHEMBL18557917 | 0.86 | GBA1 (0.55) | GBA1SPHK1GBA2GAASPHK2 | |
| SCHEMBL20726313 | 0.85 | SPHK1 (0.37) | GBA1SPHK1GBA2GAASPHK2 | |
| SCHEMBL23913040 | 0.85 | SPHK1 (0.39) | GBA1SPHK1GAASPHK2 | |
| SCHEMBL20726306 | 0.85 | SPHK1 (0.37) | GBA1SPHK1GBA2GAASPHK2 | |
| SCHEMBL20862256 | 0.85 | SPHK1 (0.39) | GBA1SPHK1GAASPHK2 | |
| SCHEMBL24319642 | 0.81 | GBA1 (0.46) | GBA1SPHK1GBA2GAASPHK2 | |
| SCHEMBL24319515 | 0.81 | GBA1 (0.46) | GBA1SPHK1GBA2GAASPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3461812-B1 | N-(5-(BIPHEN-4-YLMETHYLOXY)PENTYL)-SUBSTITUTED IMINOSUGARS AS INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE | ACAD MEDISCH CT (NL) | 2021-10-13 | — | — | EP | disclosed |