Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.46 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 7/20 | 0.35 |
| ▸ | DRD2 | P14416 | 7/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319517 | 1.00 | GBA1 (0.46) | GBA1GBA2SPHK2SPHK1GAA | |
| SCHEMBL24319515 | 1.00 | GBA1 (0.46) | GBA1GBA2SPHK2SPHK1GAA | |
| SCHEMBL20172082 | 0.83 | GBA1 (0.36) | GBA1HTR1ADRD2 | |
| SCHEMBL23912945 | 0.81 | GBA1 (0.50) | GBA1GBA2SPHK2SPHK1GAA | |
| SCHEMBL20726262 | 0.81 | GBA1 (0.50) | GBA1GBA2SPHK2SPHK1GAA | |
| SCHEMBL6628623 | 0.76 | PHGDH (0.33) | GBA1 | |
| SCHEMBL18501202 | 0.76 | GBA1 (0.39) | GBA1HTR1ADRD2 | |
| SCHEMBL7792025 | 0.75 | SPHK2 (0.56) | GBA1SPHK2SPHK1GAA | |
| SCHEMBL11983314 | 0.75 | SPHK2 (0.56) | GBA1SPHK2SPHK1GAA | |
| SCHEMBL12057010 | 0.75 | SPHK2 (0.56) | GBA1SPHK2SPHK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |