Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 16/20 | 0.39 |
| ▸ | GSK3B | P49841 | 14/20 | 0.39 |
| ▸ | WNT1 | P04628 | 11/20 | 0.39 |
| ▸ | CLK2 | P49760 | 4/20 | 0.37 |
| ▸ | CLK3 | P49761 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23048575 | 0.81 | HCAR3 (0.35) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL24218960 | 0.80 | USP30 (0.32) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916143 | 0.78 | DYRK1A (0.50) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19546597 | 0.78 | DYRK1A (0.42) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL24219182 | 0.77 | DYRK1A (0.51) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23740742 | 0.74 | GSK3B (0.53) | DYRK1AGSK3BWNT1ABL1 | |
| SCHEMBL24219201 | 0.73 | GSK3B (0.47) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL18900168 | 0.73 | ABL1 (0.57) | ABL1 | |
| SCHEMBL23740895 | 0.72 | GSK3B (0.57) | DYRK1AGSK3BWNT1 | |
| SCHEMBL24219047 | 0.72 | NNMT (0.37) | DYRK1AGSK3BWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |