Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19546973 | 0.81 | HRH3 (0.43) | WNT1GSK3BDYRK1AALDH1A1MAPT | |
| SCHEMBL19546591 | 0.79 | HRH4 (0.56) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL19547082 | 0.77 | HRH4 (0.54) | POLBMAPTSMN1; SMN2HRH4 | |
| SCHEMBL23916232 | 0.75 | HRH4 (0.39) | MAPTHRH4KDM4E | |
| SCHEMBL19546944 | 0.75 | OGA (0.40) | ALDH1A1MEN1KMT2AMAPTHRH4 | |
| SCHEMBL10147158 | 0.75 | IGF1R (0.59) | ALDH1A1MEN1KMT2AIGF1RPOLB | |
| SCHEMBL19546959 | 0.73 | HRH4 (0.38) | MAPTHRH4KDM4E | |
| SCHEMBL19546962 | 0.72 | HRH3 (0.43) | — | |
| SCHEMBL19546754 | 0.72 | HRH4 (0.54) | WNT1GSK3BDYRK1AHRH4 | |
| SCHEMBL19546657 | 0.72 | OPRD1 (0.43) | WNT1GSK3BDYRK1AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |