Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 10/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 7/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.40 |
| ▸ | MERTK | Q12866 | 7/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 7/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2397028 | 0.88 | GPR142 (0.48) | GPR142FLT3TYRO3MERTKGAS6 | |
| SCHEMBL2393491 | 0.88 | GPR142 (0.42) | GPR142FLT3TYRO3MERTKGAS6 | |
| SCHEMBL2391311 | 0.83 | GPR142 (0.63) | GPR142FLT3TYRO3MERTKGAS6 | |
| SCHEMBL2391692 | 0.80 | GPR142 (0.41) | GPR142FLT3TYRO3MERTKGAS6 | |
| SCHEMBL2395057 | 0.80 | GPR142 (0.57) | GPR142 | |
| SCHEMBL2389216 | 0.77 | GPR142 (0.77) | GPR142 | |
| SCHEMBL2397438 | 0.74 | GPR142 (0.64) | GPR142 | |
| SCHEMBL2393816 | 0.74 | GPR142 (0.75) | GPR142FLT3TYRO3MERTKGAS6 | |
| SCHEMBL2393120 | 0.72 | GPR142 (0.79) | GPR142FLT3 | |
| SCHEMBL2390813 | 0.69 | GPR142 (0.53) | GPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079728-B1 | N-ARYL PYRAZOLE COMPOUNDS FOR USE AGAINST DIABETES | AMGEN INC (US) | 2013-09-25 | — | — | EP | disclosed |
| US-8022061-B2 | 5-(Methoxymethyl)-1-(5-methyl-4-(thiophen-2-yl)pyrimidin-2-yl)-N-(pyridin-4-ylmethyl)-1H-pyrazole-4-carboxamide; for the treatment or prevention of type 2 diabetes and type 2 diabetes-related conditions | AMGEN INC. (US) | 2011-09-20 | — | — | US | disclosed |
| EP-2079728-A1 | N-ARYL PYRAZOLE COMPOUNDS FOR USE AGAINST DIABETES | Amgen Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| EP-2070093-A1 | FUNCTIONAL GRAPHENE-RUBBER NANOCOMPOSITES | The Trustees of Princeton University (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-2067146-A2 | FUNCTIONAL GRAPHENE-POLYMER NANOCOMPOSITES FOR GAS BARRIER APPLICATIONS | The Trustees of Princeton University (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008130431-A9 | FUNCTIONAL GRAPHENE-POLYMER NANOCOMPOSITES FOR GAS BARRIER APPLICATIONS | UNIV PRINCETON (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008130431-A2 | FUNCTIONAL GRAPHENE-POLYMER NANOCOMPOSITES FOR GAS BARRIER APPLICATIONS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2008-10-30 | — | — | WO | disclosed |
| US-20080153778-A1 | N-aryl pyrazole compounds, compositions, and methods for their use | AMGEN INC. | 2008-06-26 | — | — | US | disclosed |
| EP-1934139-A2 | THERMALLY EXFOLIATED GRAPHITE OXIDE | The Trustees of Princeton University (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2008045484-A1 | N-ARYL PYRAZOLE COMPOUNDS FOR USE AGAINST DIABETES | AMGEN INC. (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008045778-A1 | FUNCTIONAL GRAPHENE-RUBBER NANOCOMPOSITES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007047084-A2 | THERMALLY EXFOLIATED GRAPHITE OXIDE | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153778-A1 | N-aryl pyrazole compounds, compositions, and methods for their use | GLP1R, GPR119, NAT1 | GPR142 3378/4885JUN 3586/4885CDK2 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.