Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | SLC6A1 | P30531 | 4/20 | 0.32 |
| ▸ | SLC6A11 | P48066 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.31 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19021774 | 0.82 | KCNH2 (0.42) | KCNH2CACNA1ISLC6A1SLC6A11MEN1 | |
| SCHEMBL19958997 | 0.77 | KCNH2 (0.42) | KCNH2CACNA1ISLC6A1CYP2D6CYP2C19 | |
| SCHEMBL21784328 | 0.76 | KCNH2 (0.40) | KCNH2CACNA1IALDH1A1SMN1; SMN2 | |
| SCHEMBL29314459 | 0.72 | DRD3 (0.40) | KCNH2CACNA1IMEN1KMT2ATP53 | |
| SCHEMBL23917024 | 0.72 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL12389242 | 0.72 | ATM (0.45) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19958982 | 0.71 | SLC6A1 (0.36) | KCNH2CACNA1ISLC6A1SLC6A11MEN1 | |
| SCHEMBL25053656 | 0.71 | KCNH2 (0.42) | KCNH2CACNA1ISLC6A1CYP2D6CYP2C19 | |
| SCHEMBL14440883 | 0.70 | HPGD (0.47) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL24089450 | 0.70 | KCNH2 (0.39) | KCNH2CACNA1IALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317127-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF CANCER | ARAXES PHARMA LLC (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317127-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF CANCER | KRAS, NRAS, HRAS | KCNH2 3352/4885CACNA1I 3719/4885SLC6A1 4463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.