SCHEMBL239169

SCHEMBL239169

COC(=O)c1cc(C(=O)c2ccc(N(C)c3ccc(Cl)cc3)cn2)ccc1-n1nncc1-c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
LTC4S Q16873 20/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL240736 0.92 LTC4S (0.59) LTC4S
SCHEMBL559486 0.92 LTC4S (0.43) LTC4S
SCHEMBL2755497 0.87 LTC4S (0.56) LTC4S
SCHEMBL238391 0.85 LTC4S (0.55) LTC4S
SCHEMBL559628 0.83 LTC4S (0.47) LTC4S
SCHEMBL236561 0.80 LTC4S (0.73) LTC4S
SCHEMBL2755502 0.79 LTC4S (0.60) LTC4S
SCHEMBL560196 0.79 LTC4S (0.47) LTC4S
SCHEMBL240004 0.78 LTC4S (0.46) LTC4S
SCHEMBL238185 0.78 LTC4S (0.61) LTC4S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2197495-A2 LIPOPEPTIDES FOR DELIVERY OF NUCLEIC ACIDS MDRNA, Inc. (US) 2010-06-23 EP claimed
EP-2157982-A2 AMINO ACID LIPIDS AND USES THEREOF MDRNA, Inc. (US) 2010-03-03 EP claimed
WO-2009046220-A2 LIPOPEPTIDES FOR DELIVERY OF NUCLEIC ACIDS MDRNA, INC. (US) 2009-04-09 WO claimed
WO-2008137758-A2 AMINO ACID LIPIDS AND USES THEREOF MDRNA, INC. (US) 2008-11-13 WO claimed
CN-105612217-B Crosslinking composition having excellent storage stability 株式会社大阪曹达 2018-05-22 CN disclosed
CN-107207983-A Use of a lubricating composition 国际壳牌研究有限公司 2017-09-26 CN disclosed
EP-2785178-A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE Bikam Pharmaceuticals, Inc. (US) 2014-10-08 EP disclosed
WO-2013081642-A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE BIKAM PHARMACEUTICALS, INC. (US) 2013-06-06 WO disclosed
EP-2443087-A1 DISUBSTITUTED-AMINODIFLUOROSULFINIUM SALTS, PROCESS FOR PREPARING SAME AND METHOD OF USE AS DEOXOFLUORINATION REAGENTS Omegachem Inc. (CA) 2012-04-25 EP disclosed
EP-2429994-A1 BIS AROMATIC COMPOUNDS FOR USE AS LTC4 SYNTHASE INHIBITORS Biolipox AB (SE) 2012-03-21 EP disclosed
US-20120035217-A1 Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors BIOLIPOX AB (SW) 2012-02-09 US disclosed
EP-2406220-A1 BIS AROMATIC COMPOUNDS FOR USE AS LTC4 SYNTHASE INHIBITORS Biolipox AB (SE) 2012-01-18 EP disclosed
EP-2300456-A1 BICYCLIC COMPOUNDS HAVING ACTIVITY AT THE CXCR4 RECEPTOR Allergan, Inc. (US) 2011-03-30 EP disclosed
EP-2296711-A2 MULTI-ARM AMINES AND USES THEREOF MDRNA, Inc. (US) 2011-03-23 EP disclosed
WO-2010145037-A1 DISUBSTITUTED-AMINODIFLUOROSULFINIUM SALTS, PROCESS FOR PREPARING SAME AND METHOD OF USE AS DEOXOFLUORINATION REAGENTS OMEGACHEM INC. (CA) 2010-12-23 WO disclosed
WO-2010103283-A1 BIS AROMATIC COMPOUNDS FOR USE AS LTC4 SYNTHASE INHIBITORS BIOLIPOX AB (SE) 2010-09-16 WO disclosed
EP-2157982-A2 AMINO ACID LIPIDS AND USES THEREOF MDRNA, Inc. (US) 2010-03-03 EP disclosed
WO-2009148955-A2 MULTI-ARM AMINES AND USES THEREOF MDRNA, INC (US) 2009-12-10 WO disclosed
WO-2008137758-A2 AMINO ACID LIPIDS AND USES THEREOF MDRNA, INC. (US) 2008-11-13 WO disclosed
EP-0202697-B1 SEPARATION PROCESS FOR PARA-FLUORO-ANILINE SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1991-12-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035217-A1 Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors LTC4S, LTB4R2, LTB4R LTC4S 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.