Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.49 |
| ▸ | AGXT | P21549 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21566486 | 0.86 | SIRT6 (0.59) | SIRT6HTR6HTR3ADRD2DRD3 | |
| SCHEMBL8325286 | 0.82 | AGXT (0.44) | SIRT6HTR6AGXTHTR3AKDM4E | |
| SCHEMBL13243994 | 0.80 | SIRT6 (0.63) | SIRT6HTR6HTR3ADRD2DRD3 | |
| SCHEMBL22652120 | 0.79 | GAA (0.58) | SIRT6HTR6AGXTHTR3AKDM4E | |
| SCHEMBL30602337 | 0.79 | AGXT (0.44) | SIRT6HTR6AGXTHTR3AKDM4E | |
| SCHEMBL1911875 | 0.78 | SIRT6 (0.60) | SIRT6HTR6HTR3ADRD2DRD3 | |
| SCHEMBL438444 | 0.76 | MAPT (0.63) | SIRT6HTR6HTR3ADRD2DRD3 | |
| SCHEMBL24992445 | 0.76 | SIRT6 (0.58) | SIRT6HTR6HTR3ADRD2DRD3 | |
| SCHEMBL14145814 | 0.76 | SIRT6 (0.58) | SIRT6HTR6HTR3ADRD2DRD3 | |
| SCHEMBL24783778 | 0.76 | SIRT6 (0.58) | SIRT6HTR6HTR3ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11344553-B2 | Substituted pyrazolopyrimidines useful as kinases inhibitors | TELIGENE LTD. (CN) | 2022-05-31 | — | — | US | disclosed |
| US-20210315899-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS KINASES INHIBITORS | TELIGENE LTD. (CN) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210315899-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS KINASES INHIBITORS | MAP3K20, MAP3K6, MAP3K8 | SIRT6 2006/4885HTR6 3762/4885AGXT 2738/4885 |
| US-11344553-B2 | Substituted pyrazolopyrimidines useful as kinases inhibitors | MAP3K20, PRKDC, MAP3K6 | SIRT6 1971/4885HTR6 3465/4885AGXT 2596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.