Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23917510 | 0.85 | NOTUM (0.43) | NOTUMMTNR1AMTNR1BSMN1; SMN2HSD17B3 | |
| SCHEMBL21172497 | 0.80 | NOTUM (0.61) | NOTUMMTNR1AMTNR1BSMN1; SMN2HSD17B3 | |
| SCHEMBL21172644 | 0.80 | NOTUM (0.61) | NOTUMMTNR1AMTNR1BSMN1; SMN2HSD17B3 | |
| SCHEMBL26517034 | 0.79 | NOTUM (0.51) | NOTUMMTNR1AMTNR1BSMN1; SMN2HSD17B3 | |
| SCHEMBL7352202 | 0.78 | AVPR2 (0.56) | NOTUMSMN1; SMN2HSD17B3ALDH1A1NPC1 | |
| SCHEMBL21172618 | 0.77 | NOTUM (0.49) | NOTUMMTNR1AMTNR1BSMN1; SMN2ALDH1A1 | |
| SCHEMBL26517033 | 0.77 | NOTUM (0.49) | NOTUMMTNR1AMTNR1BSMN1; SMN2ALDH1A1 | |
| SCHEMBL23917466 | 0.77 | NOTUM (0.49) | NOTUMMTNR1AMTNR1BSMN1; SMN2ALDH1A1 | |
| SCHEMBL23917198 | 0.75 | NOTUM (0.48) | NOTUMMTNR1AMTNR1BSMN1; SMN2HSD17B3 | |
| SCHEMBL16353667 | 0.74 | NOTUM (0.47) | NOTUMSMN1; SMN2RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | NOTUM 2740/4885MTNR1A 4845/4885MTNR1B 4784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.