Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MME | P08473 | 3/20 | 0.43 |
| ▸ | ACE | P12821 | 3/20 | 0.43 |
| ▸ | CPA1 | P15085 | 3/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23917936 | 0.89 | KMT2A (0.48) | KMT2APPARGLMNAPPARAACACB | |
| SCHEMBL12839670 | 0.86 | KMT2A (0.46) | KMT2APPARGLMNAPPARAACACB | |
| SCHEMBL25764848 | 0.83 | TDP1 (0.52) | KMT2APPARGPPARAFOLH1TDP1 | |
| SCHEMBL25764849 | 0.83 | TDP1 (0.52) | KMT2APPARGPPARAFOLH1TDP1 | |
| SCHEMBL547121 | 0.83 | FOLH1 (0.61) | KMT2AFOLH1MEN1MMEACE | |
| SCHEMBL1287829 | 0.83 | FOLH1 (0.61) | KMT2AFOLH1MEN1MMEACE | |
| SCHEMBL18067342 | 0.83 | KMT2A (0.55) | KMT2APPARGLMNAPPARAFOLH1 | |
| SCHEMBL547122 | 0.83 | FOLH1 (0.61) | KMT2AFOLH1MEN1MMEACE | |
| SCHEMBL14535511 | 0.83 | KMT2A (0.43) | KMT2APPARGLMNAPPARAACACB | |
| SCHEMBL7271174 | 0.83 | SIGMAR1 (0.56) | LMNAFOLH1MMEACECPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892305-A1 | HEMIASTERLIN DERIVATIVES FOR CONJUGATION AND THERAPY | Sutro Biopharma, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |